Atypical fibroxanthoma (AFX) is a dermal spindle-cell tumour that typically occurs on the head and neck of sun damaged older people. The tumour-like growth should be considered a type of skin cancer but it may behave in a benign fashion. A rare type of atypical fibroxanthoma occurs in younger patients on parts of the body that are not normally overexposed to the sun.

Definition. A morphologic variant of atypical fibroxanthoma characterized by the presence of spindle-shaped fibrohistiocytic cells and a storiform growth pattern. [from NCI]

It comprises up to 0,2% of all skin tumors (1). AFX is considered to be benign tumor with excellent prognosis after complete surgical excision with free margins. Atypical Fibroxanthoma - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the MSD Manuals - Medical Professional Version. Atypical fibroxanthoma (AFX) is a dermal spindle-cell tumour that typically occurs on the head and neck of sun damaged older people. The tumour-like growth should be considered a type of skin cancer but it may behave in a benign fashion. A rare type of atypical fibroxanthoma occurs in younger patients on parts of the body that are not normally overexposed to the sun. Atypical fibroxanthoma prognosis.

Atypical fibroxanthoma prognosis

Diagnosis is made by immunohistochemistry. 2017-12-08 Treatment and prognosis Atypical fibroxanthomas are surgically removed and have a good prognosis. They might locally reoccur with the necessity of re-surgery. Metastatic spread has … Atypical fibroxanthoma (AFX) is a rare, rapidly growing mesenchymal neoplasm that often presents on sun-exposed head and neck regions of older individuals. The diagnosis relies on knowledge of its clinical and histological features combined with immunohistochemistry markers used primarily to exclude other cutaneous neoplasms that may share Atypical fibroxanthoma (AFX) was first described by Helwig as a low-grade sarcoma with a favorable prognosis .

Atypical fibroxanthoma (AFX) is a cutaneous sarcoma of potential and a poor prognosis include tumor 5-year survival than proximal tumors.56,59,60.

They were located on the face or scalp, but in nine cases also on the limbs. Atypical fibroxanthomas are uncommon but usually occur on the head and neck of older people. They may look like other skin cancers (other than melanoma) and often appear as pink-red raised areas or bumps that do not heal and may be tender. Atypical fibroxanthoma (AFX) is an uncommon cutaneous neoplasm that usually presents as a rapidly-growing nodule in sun-exposed sites in elderly patients.

has an excellent prognosis, b ut long-term follow-up is recommended due to the potential for aggr essive behavior. Atypical fibroxanthoma (AFX) is a rare primary mesenchymal skin tumor of

This video discusses the basic workup of a pleomorphic malignant cutaneous spindle cell tumor. The main differential diagnosis includes spindle cell melanoma As expected, overall survival was relatively low (5-year survival: 88.7%, 10-year survival: 86.9%, 20-year survival: 85.6%), mainly due to old age and existing co- Atypical fibroxanthoma (AFX) typically presents with the sudden onset of an asymptomatic, solitary, growth of the head and neck. Bleeding and ulceration are Atypical fibroxanthoma is a malignant skin tumor with histologic features similar to those of undifferentiated Mar 16, 2021 Skin nonmelanocytic tumor - Atypical fibroxanthoma (AFX), Rare, low grade, malignant cutaneous tumor of uncertain differentiation, first Atypical fibroxanthoma causes. The etiology of atypical fibroxanthomas is poorly understood.

Larger tumors (>2 cm) which extensively invade subcutaneous tissue such as fascia or muscle, or show The term atypical fibroxanthoma (AFX) was used in 1961 by Helwig for indicate a typically nodular ulcerative lesion arising from the sun-exposed skin of the head and neck. Rarely AFX has been described in young and in areas without evidence of actinic damage. Atypical fibroxanthomas are uncommon but usually occur on the head and neck of older people. They may look like other skin cancers (other than melanoma) and often appear as pink-red raised areas or bumps that do not heal and may be tender. Atypical fibroxanthoma presents as a dermally based, circumscribed lesion with overlying epidermal collarette, central ulceration, and parakeratosis (Figure 1, A and B). Mild to severe solar elastosis is regularly encountered adjacent to the tumor. Is Atypical Fibroxanthoma hereditary? No. What are the symptoms of Atypical Fibroxanthoma?
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Due to its low rate of metastasis, it is considered a benign neoplasm [1,2].

Recurrences are infrequent, and metastasis is rare. Atypical fibroxanthoma is a type of skin cancer which is often misdiagnosed as a less serious skin condition.
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Atypical fibroxanthoma (AFX) is an ultraviolet radiation-associated dermal neoplasm. To address the clinicopathologic and molecular features of this particular neoplasm. The author conducted a literature review using PubMed searching for articles relating to AFX. AFX usually appears as a rapidly growing nodular or nodulo-ulcerative lesion.

Atypical fibroxanthoma (AFX) is a rare, low-grade malignant mesenchymal neoplasm of the dermis. It arises on sun-damaged skin in primarily older male patients as a solitary ulcerated nodule on the head and neck. Clinically, it grows rapidly without any pain or local invasion, and metastasis is rarely seen. Atypical fibroxanthoma prognosis Atypical fibroxanthoma rarely recurs after complete excision with clear margins. Recurrence and metastasis are more likely in people that are immunosuppressed. Fortunately, atypical fibroxanthoma rarely metastasizes and recurs in only 6% to 10% of cases 6).